Does a H1-B sponsorship demand decrease your chance of getting a job?

Can anyone share their experience in jobhunting regarding H1B visa sponsorship ? Does that influence your job prospects in the US?

yes, require a sponsorship is a huge debuff, unless you are super intelligent or your hard skills are too unique and uncopiable.
I applied for 1000+ positions with 500+ customized resumes, only got 10 calls, and still no offer yet.